MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.
Identifieur interne : 000C65 ( Main/Exploration ); précédent : 000C64; suivant : 000C66MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.
Auteurs : Vineet D. Menachery [États-Unis] ; Alexandra Sch Fer [États-Unis] ; Kristin E. Burnum-Johnson [États-Unis] ; Hugh D. Mitchell [États-Unis] ; Amie J. Eisfeld [États-Unis] ; Kevin B. Walters [États-Unis] ; Carrie D. Nicora [États-Unis] ; Samuel O. Purvine [États-Unis] ; Cameron P. Casey [États-Unis] ; Matthew E. Monroe [États-Unis] ; Karl K. Weitz [États-Unis] ; Kelly G. Stratton [États-Unis] ; Bobbie-Jo M. Webb-Robertson [États-Unis] ; Lisa E. Gralinski [États-Unis] ; Thomas O. Metz [États-Unis] ; Richard D. Smith [États-Unis] ; Katrina M. Waters [États-Unis] ; Amy C. Sims [États-Unis] ; Yoshihiro Kawaoka [États-Unis] ; Ralph S. Baric [États-Unis]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Cadres ouverts de lecture, Cellules Vero, Cellules rénales canines Madin-Darby, Chiens, Complexe majeur d'histocompatibilité, Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Histone (), Humains, Lignée cellulaire, Mutation, Méthylation de l'ADN, Protéomique, Présentation d'antigène, Régulation négative, Sous-type H5N1 du virus de la grippe A (pathogénicité), Variation des antigènes, Épigenèse génétique.
- MESH :
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Sous-type H5N1 du virus de la grippe A.
- Animaux, Cadres ouverts de lecture, Cellules Vero, Cellules rénales canines Madin-Darby, Chiens, Complexe majeur d'histocompatibilité, Histone, Humains, Lignée cellulaire, Mutation, Méthylation de l'ADN, Protéomique, Présentation d'antigène, Régulation négative, Variation des antigènes, Épigenèse génétique.
English descriptors
- KwdEn :
- Animals, Antigen Presentation, Antigenic Variation, Cell Line, Chlorocebus aethiops, DNA Methylation, Dogs, Down-Regulation, Epigenesis, Genetic, Histones (chemistry), Humans, Influenza A Virus, H5N1 Subtype (pathogenicity), Madin Darby Canine Kidney Cells, Major Histocompatibility Complex, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Mutation, Open Reading Frames, Proteomics, Vero Cells.
- MESH :
- chemical , chemistry : Histones.
- pathogenicity : Influenza A Virus, H5N1 Subtype, Middle East Respiratory Syndrome Coronavirus.
- Animals, Antigen Presentation, Antigenic Variation, Cell Line, Chlorocebus aethiops, DNA Methylation, Dogs, Down-Regulation, Epigenesis, Genetic, Humans, Madin Darby Canine Kidney Cells, Major Histocompatibility Complex, Mutation, Open Reading Frames, Proteomics, Vero Cells.
Abstract
Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined differential regulation of IFN-γ-dependent genes following infection with robust respiratory viruses including influenza viruses [A/influenza/Vietnam/1203/2004 (H5N1-VN1203) and A/influenza/California/04/2009 (H1N1-CA04)] and coronaviruses [severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV)]. Categorizing by function, we observed down-regulation of gene expression associated with antigen presentation following both H5N1-VN1203 and MERS-CoV infection. Further examination revealed global down-regulation of antigen-presentation gene expression, which was confirmed by proteomics for both H5N1-VN1203 and MERS-CoV infection. Importantly, epigenetic analysis suggested that DNA methylation, rather than histone modification, plays a crucial role in MERS-CoV-mediated antagonism of antigen-presentation gene expression; in contrast, H5N1-VN1203 likely utilizes a combination of epigenetic mechanisms to target antigen presentation. Together, the results indicate a common mechanism utilized by H5N1-VN1203 and MERS-CoV to modulate antigen presentation and the host adaptive immune response.
DOI: 10.1073/pnas.1706928115
PubMed: 29339515
Affiliations:
- États-Unis
- Caroline du Nord, Texas, Washington (État), Wisconsin
- Chapel Hill (Caroline du Nord), Madison (Wisconsin)
- Université de Caroline du Nord à Chapel Hill, Université du Wisconsin à Madison
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Le document en format XML
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Sims</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="1"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706; yoshihiro.kawaoka@wisc.edu rbaric@email.unc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison</wicri:regionArea><wicri:noRegion>Madison</wicri:noRegion><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; yoshihiro.kawaoka@wisc.edu rbaric@email.unc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29339515</idno><idno type="pmid">29339515</idno><idno type="doi">10.1073/pnas.1706928115</idno><idno type="wicri:Area/PubMed/Corpus">000A31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A31</idno><idno type="wicri:Area/PubMed/Curation">000A31</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A31</idno><idno type="wicri:Area/PubMed/Checkpoint">000991</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000991</idno><idno type="wicri:Area/Ncbi/Merge">002F01</idno><idno type="wicri:Area/Ncbi/Curation">002F01</idno><idno type="wicri:Area/Ncbi/Checkpoint">002F01</idno><idno type="wicri:Area/Main/Merge">000C67</idno><idno type="wicri:Area/Main/Curation">000C65</idno><idno type="wicri:Area/Main/Exploration">000C65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.</title><author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston</wicri:cityArea></affiliation></author><author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Burnum Johnson, Kristin E" sort="Burnum Johnson, Kristin E" uniqKey="Burnum Johnson K" first="Kristin E" last="Burnum-Johnson">Kristin E. Burnum-Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Hugh D" sort="Mitchell, Hugh D" uniqKey="Mitchell H" first="Hugh D" last="Mitchell">Hugh D. Mitchell</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J" last="Eisfeld">Amie J. Eisfeld</name><affiliation wicri:level="2"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Walters, Kevin B" sort="Walters, Kevin B" uniqKey="Walters K" first="Kevin B" last="Walters">Kevin B. Walters</name><affiliation wicri:level="2"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Nicora, Carrie D" sort="Nicora, Carrie D" uniqKey="Nicora C" first="Carrie D" last="Nicora">Carrie D. Nicora</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Purvine, Samuel O" sort="Purvine, Samuel O" uniqKey="Purvine S" first="Samuel O" last="Purvine">Samuel O. Purvine</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Casey, Cameron P" sort="Casey, Cameron P" uniqKey="Casey C" first="Cameron P" last="Casey">Cameron P. Casey</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Monroe, Matthew E" sort="Monroe, Matthew E" uniqKey="Monroe M" first="Matthew E" last="Monroe">Matthew E. Monroe</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Weitz, Karl K" sort="Weitz, Karl K" uniqKey="Weitz K" first="Karl K" last="Weitz">Karl K. Weitz</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Stratton, Kelly G" sort="Stratton, Kelly G" uniqKey="Stratton K" first="Kelly G" last="Stratton">Kelly G. Stratton</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Webb Robertson, Bobbie Jo M" sort="Webb Robertson, Bobbie Jo M" uniqKey="Webb Robertson B" first="Bobbie-Jo M" last="Webb-Robertson">Bobbie-Jo M. Webb-Robertson</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E" last="Gralinski">Lisa E. Gralinski</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O" last="Metz">Thomas O. Metz</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D" last="Smith">Richard D. Smith</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M" last="Waters">Katrina M. Waters</name><affiliation wicri:level="2"><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Biological Sciences Division, Pacific Northwest National Laboratory, Richland</wicri:cityArea></affiliation></author><author><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C" last="Sims">Amy C. Sims</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="1"><nlm:affiliation>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706; yoshihiro.kawaoka@wisc.edu rbaric@email.unc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison</wicri:regionArea><wicri:noRegion>Madison</wicri:noRegion><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; yoshihiro.kawaoka@wisc.edu rbaric@email.unc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigen Presentation</term><term>Antigenic Variation</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>DNA Methylation</term><term>Dogs</term><term>Down-Regulation</term><term>Epigenesis, Genetic</term><term>Histones (chemistry)</term><term>Humans</term><term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term><term>Madin Darby Canine Kidney Cells</term><term>Major Histocompatibility Complex</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>Mutation</term><term>Open Reading Frames</term><term>Proteomics</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Cellules Vero</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Complexe majeur d'histocompatibilité</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Histone ()</term><term>Humains</term><term>Lignée cellulaire</term><term>Mutation</term><term>Méthylation de l'ADN</term><term>Protéomique</term><term>Présentation d'antigène</term><term>Régulation négative</term><term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term><term>Variation des antigènes</term><term>Épigenèse génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Histones</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antigen Presentation</term><term>Antigenic Variation</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>DNA Methylation</term><term>Dogs</term><term>Down-Regulation</term><term>Epigenesis, Genetic</term><term>Humans</term><term>Madin Darby Canine Kidney Cells</term><term>Major Histocompatibility Complex</term><term>Mutation</term><term>Open Reading Frames</term><term>Proteomics</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Cellules Vero</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Complexe majeur d'histocompatibilité</term><term>Histone</term><term>Humains</term><term>Lignée cellulaire</term><term>Mutation</term><term>Méthylation de l'ADN</term><term>Protéomique</term><term>Présentation d'antigène</term><term>Régulation négative</term><term>Variation des antigènes</term><term>Épigenèse génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined differential regulation of IFN-γ-dependent genes following infection with robust respiratory viruses including influenza viruses [A/influenza/Vietnam/1203/2004 (H5N1-VN1203) and A/influenza/California/04/2009 (H1N1-CA04)] and coronaviruses [severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV)]. Categorizing by function, we observed down-regulation of gene expression associated with antigen presentation following both H5N1-VN1203 and MERS-CoV infection. Further examination revealed global down-regulation of antigen-presentation gene expression, which was confirmed by proteomics for both H5N1-VN1203 and MERS-CoV infection. Importantly, epigenetic analysis suggested that DNA methylation, rather than histone modification, plays a crucial role in MERS-CoV-mediated antagonism of antigen-presentation gene expression; in contrast, H5N1-VN1203 likely utilizes a combination of epigenetic mechanisms to target antigen presentation. Together, the results indicate a common mechanism utilized by H5N1-VN1203 and MERS-CoV to modulate antigen presentation and the host adaptive immune response.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Texas</li><li>Washington (État)</li><li>Wisconsin</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li><li>Madison (Wisconsin)</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li><li>Université du Wisconsin à Madison</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name></region><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><name sortKey="Burnum Johnson, Kristin E" sort="Burnum Johnson, Kristin E" uniqKey="Burnum Johnson K" first="Kristin E" last="Burnum-Johnson">Kristin E. Burnum-Johnson</name><name sortKey="Casey, Cameron P" sort="Casey, Cameron P" uniqKey="Casey C" first="Cameron P" last="Casey">Cameron P. Casey</name><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J" last="Eisfeld">Amie J. Eisfeld</name><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E" last="Gralinski">Lisa E. Gralinski</name><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O" last="Metz">Thomas O. Metz</name><name sortKey="Mitchell, Hugh D" sort="Mitchell, Hugh D" uniqKey="Mitchell H" first="Hugh D" last="Mitchell">Hugh D. Mitchell</name><name sortKey="Monroe, Matthew E" sort="Monroe, Matthew E" uniqKey="Monroe M" first="Matthew E" last="Monroe">Matthew E. Monroe</name><name sortKey="Nicora, Carrie D" sort="Nicora, Carrie D" uniqKey="Nicora C" first="Carrie D" last="Nicora">Carrie D. Nicora</name><name sortKey="Purvine, Samuel O" sort="Purvine, Samuel O" uniqKey="Purvine S" first="Samuel O" last="Purvine">Samuel O. Purvine</name><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C" last="Sims">Amy C. Sims</name><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D" last="Smith">Richard D. Smith</name><name sortKey="Stratton, Kelly G" sort="Stratton, Kelly G" uniqKey="Stratton K" first="Kelly G" last="Stratton">Kelly G. Stratton</name><name sortKey="Walters, Kevin B" sort="Walters, Kevin B" uniqKey="Walters K" first="Kevin B" last="Walters">Kevin B. Walters</name><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M" last="Waters">Katrina M. Waters</name><name sortKey="Webb Robertson, Bobbie Jo M" sort="Webb Robertson, Bobbie Jo M" uniqKey="Webb Robertson B" first="Bobbie-Jo M" last="Webb-Robertson">Bobbie-Jo M. Webb-Robertson</name><name sortKey="Weitz, Karl K" sort="Weitz, Karl K" uniqKey="Weitz K" first="Karl K" last="Weitz">Karl K. Weitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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